Recurrent IVF Failure
Recurrent IVF Failure
Recurrent IVF Failure refers to the inability to achieve a successful pregnancy after multiple well-executed IVF cycles despite transferring good-quality embryos. This condition requires detailed evaluation, personalized treatment, and advanced reproductive strategies to improve success rates.
Possible Causes
- Poor embryo quality
- Uterine abnormalities
- Thin endometrial lining
- Hormonal imbalance
- Genetic factors
- Immunological issues
- Sperm DNA fragmentation
- Implantation failure
Evaluation & Diagnostic Approach
1. Comprehensive Medical Review
- Previous IVF cycle analysis
- Hormonal profile assessment
- Genetic screening (if required)
2. Uterine Assessment
- Hysteroscopy
- Saline sonography
- Endometrial biopsy (if needed)
3. Embryo & Sperm Testing
- PGT/PGD genetic screening
- Sperm DNA fragmentation test
Success Improvement Measures
1. Personalized IVF Protocol
- Adjusted ovarian stimulation plan
- Customized medication dosage
2. Advanced Embryo Selection
- Time-lapse embryo monitoring
- Genetic testing (PGT-A)
3. Endometrial Optimization
- Hormonal therapy to improve lining
- Immune therapy (if indicated)
4. ICSI / Laser Assisted Hatching
- Used to enhance fertilization and implantation
Success Improvement Measures
- Better embryo selection
- Improved uterine receptivity
- Tailored treatment protocol
- Multidisciplinary expert care
